Three-dimensional genome rewiring during the development of antibody-secreting cells
Journal Title
Biochemical Society Transactions
Publication Type
Journal epub ahead of print
Abstract
The development of B lymphocytes into antibody-secreting plasma cells is central to the adaptive immune system in that it confers protective and specific antibody response against invading pathogen. This developmental process involves extensive morphological and functional alterations that begin early after antigenic stimulation. These include chromatin restructuring that is critical in regulating gene expression, DNA rearrangement and other cellular processes. Here we outline the recent understanding of the three-dimensional architecture of the genome, specifically focused on its contribution to the process of B cell activation and terminal differentiation into antibody-secreting cells.
Publisher
Portland Press
WEHI Research Division(s)
Immunology
PubMed ID
32453419
Open Access at Publisher's Site
https://doi.org/10.1042/BST20191104
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2020-06-03 09:37:45
Last Modified: 2020-06-03 09:46:31
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