Loss of NF-kB1 and c-Rel accelerates oral carcinogenesis in mice
- Author(s)
- Ni, Y; Yap, T; Silke, N; Silke, J; McCullough, M; Celentano, A; O'Reilly, LA;
- Details
- Publication Year 2020-06-22,Volume 27,Issue #2,Page 168-172
- Journal Title
- Oral Diseases
- Abstract
- Oral squamous cell carcinoma (OSCC) is a major subcategory of head and neck squamous cell carcinomas (HNSCC) and is currently the 6(th) highest cause of cancer mortality world-wide (Bray et al., 2018; Siegel, Miller, & Jemal, 2019). Despite current treatments such as surgery with adjunctive radiation and chemotherapy, the 5-year survival has remained at 50% for decades (Kumar, Nanavati, Modi, & Dobariya, 2016; Rivera, 2015). Most human solid cancers are believed to be driven by chronic inflammation that instigates nascent tumour proliferation (dysplasia), transformation and metastasis while conversely suppressing anti-tumour immune responses (Taniguchi & Karin, 2018). Inflammation promoted by dysregulated NF-kappaB (nuclear factor of kappa B) is also a hallmark of early OSCC (Cancer Genome Atlas, 2015; Tang et al., 2015). Lack of knowledge of this molecular driver is a key feature limiting curative outcomes.
- Publisher
- Wiley
- Research Division(s)
- Inflammation
- PubMed ID
- 32568418
- Publisher's Version
- https://doi.org/10.1111/odi.13508
- NHMRC Grants
- NHMRC/1107149,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-06-25 07:59:32
Last Modified: 2021-06-21 12:14:59