Lyn, lupus, and (B) lymphocytes, a lesson on the critical balance of kinase signaling in immunity
- Author(s)
- Brodie, EJ; Infantino, S; Low, MSY; Tarlinton, DM;
- Journal Title
- Frontiers in Immunology
- Publication Type
- Journal Article
- Abstract
- Systemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by increased sensitivity to self-antigens, auto-antibody production, and systemic inflammation. B cells have been implicated in disease progression and as such represent an attractive therapeutic target. Lyn is a Src family tyrosine kinase that plays a major role in regulating signaling pathways within B cells as well as other hematopoietic cells. Its role in initiating negative signaling cascades is especially critical as exemplified by Lyn-/- mice developing an SLE-like disease with plasma cell hyperplasia, underscoring the importance of tightly regulating signaling within B cells. This review highlights recent advances in our understanding of the function of the Src family tyrosine kinase Lyn in B lymphocytes and its contribution to positive and negative signaling pathways that are dysregulated in autoimmunity. © 2018 Brodie, Infantino, Low and Tarlinton.
- Publisher
- Frontiers Media S.A.
- Keywords
- Autoimmunity; B cell; Cell signaling; Lupus;
- Research Division(s)
- Immunology
- PubMed ID
- 29545808
- Publisher's Version
- https://doi.org/10.3389/fimmu.2018.00401
- Open Access at Publisher's Site
https://doi.org/10.3389/fimmu.2018.00401- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-03-19 10:02:29
Last Modified: 2018-03-19 10:16:17