Lyn, lupus, and (B) lymphocytes, a lesson on the critical balance of kinase signaling in immunity
Journal Title
Frontiers in Immunology
Publication Type
Journal Article
Abstract
Systemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by increased sensitivity to self-antigens, auto-antibody production, and systemic inflammation. B cells have been implicated in disease progression and as such represent an attractive therapeutic target. Lyn is a Src family tyrosine kinase that plays a major role in regulating signaling pathways within B cells as well as other hematopoietic cells. Its role in initiating negative signaling cascades is especially critical as exemplified by Lyn-/- mice developing an SLE-like disease with plasma cell hyperplasia, underscoring the importance of tightly regulating signaling within B cells. This review highlights recent advances in our understanding of the function of the Src family tyrosine kinase Lyn in B lymphocytes and its contribution to positive and negative signaling pathways that are dysregulated in autoimmunity. © 2018 Brodie, Infantino, Low and Tarlinton.
Publisher
Frontiers Media S.A.
Keywords
Autoimmunity; B cell; Cell signaling; Lupus;
WEHI Research Division(s)
Immunology
PubMed ID
29545808
Open Access at Publisher's Site
https://doi.org/10.3389/fimmu.2018.00401
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2018-03-19 10:02:29
Last Modified: 2018-03-19 10:16:17
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