Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax

Gruszczyk, J; Kanjee, U; Chan, LJ; Menant, S; Malleret, B; Lim, NTY; Schmidt, CQ; Mok, YF; Lin, KM; Pearson, RD; Rangel, G; Smith, BJ; Call, MJ; Weekes, MP; Griffin, MDW; Murphy, JM; Abraham, J; Sriprawat, K; Menezes, MJ; Ferreira, MU; Russell, B; Renia, L; Duraisingh, MT; Tham, WH

Author(s): Gruszczyk, J; Kanjee, U; Chan, LJ; Menant, S; Malleret, B; Lim, NTY; Schmidt, CQ; Mok, YF; Lin, KM; Pearson, RD; Rangel, G; Smith, BJ; Call, MJ; Weekes, MP; Griffin, MDW; Murphy, JM; Abraham, J; Sriprawat, K; Menezes, MJ; Ferreira, MU; Russell, B; Renia, L; Duraisingh, MT; Tham, WH;
Details: Publication Year 2018-01-05,Volume 359,Issue #6371,Page 48-55
Journal Title: Science
Publication Type: Journal Article
Abstract: Plasmodium vivax shows a strict host tropism for reticulocytes. We identified transferrin receptor 1 (TfR1) as the receptor for P. vivax reticulocyte-binding protein 2b (PvRBP2b). We determined the structure of the N-terminal domain of PvRBP2b involved in red blood cell binding, elucidating the molecular basis for TfR1 recognition. We validated TfR1 as the biological target of PvRBP2b engagement by means of TfR1 expression knockdown analysis. TfR1 mutant cells deficient in PvRBP2b binding were refractory to invasion of P. vivax but not to invasion of P. falciparum Using Brazilian and Thai clinical isolates, we show that PvRBP2b monoclonal antibodies that inhibit reticulocyte binding also block P. vivax entry into reticulocytes. These data show that TfR1-PvRBP2b invasion pathway is critical for the recognition of reticulocytes during P. vivax invasion.
Publisher: AAAS
Research Division(s): Structural Biology; Infection And Immunity; Cell Signalling And Cell Death
PubMed ID: 29302006
Publisher's Version: https://doi.org/10.1126/science.aan1078
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2018-02-27 12:35:03

Last Modified: 2018-02-27 01:13:02