Therapeutic manipulation of host cell death pathways to facilitate clearance of persistent viral infections
- Author(s)
- Cooney, J; Allison, C; Preston, S; Pellegrini, M;
- Details
- Publication Year 2018-02,Volume 103,Issue #2,Page 287-293
- Journal Title
- J Leukoc Biol
- Publication Type
- Journal Article
- Abstract
- Most persistent viral infections can be controlled, but not cured, by current therapies. Abrogated antiviral immunity and stable latently infected cells represent major barriers to cure. This necessitates life-long suppressive antiviral therapy. Achieving a cure for HIV, hepatitis B virus, Epstein Barr-virus, and others, requires novel approaches to facilitate the clearance of infected cells from the host. One such approach is to target host cell death pathways, rather than the virus itself. Here, we summarize recent findings from studies that have utilized therapeutics to manipulate host cell death pathways as a means to treat and cure persistent viral infections.
- Publisher
- Wiley
- Research Division(s)
- Infection And Immunity
- PubMed ID
- 29345371
- Publisher's Version
- https://doi.org/10.1189/JLB.3MR0717-289R
- NHMRC Grants
- NHMRC/1006592, NHMRC/1045549, NHMRC/1065626,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-02-27 12:34:59
Last Modified: 2018-02-27 01:11:13