Detection and localization of surgically resectable cancers with a multi-analyte blood test
Details
Publication Year 2018-01-18, Volume 359, Issue #6378, Page 926-930
Journal Title
Science
Publication Type
Journal Article
Abstract
Earlier detection is key to reducing cancer deaths. Here we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1,005 patients with non-metastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69% to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was > 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients.
Publisher
AAAS
WEHI Research Division(s)
Systems Biology And Personalised Medicine
PubMed ID
29348365
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2018-02-27 12:34:59
Last Modified: 2018-02-27 01:01:51
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