In vivo models of inflammatory bowel disease and colitis-associated cancer
- Author(s)
- Fung, KY; Putoczki, T;
- Journal Title
- Inflammation and Cancer. Methods in Molecular Biology, vol 1725
- Publication Type
- Book Section
- Abstract
- A single layer of epithelial cells separates luminal antigens from the host immune system throughout the gastrointestinal tract. A breakdown in the integrity of the epithelial barrier can lead to chronic inflammation, which is associated with numerous complications including cancer. Here we describe three experimental protocols to chemically induce acute and chronic inflammatory bowel disease (IBD) symptoms and colitis-associated colorectal cancer (CRC) progression. These in vivo mouse models are based on the induction of damage to the colonic epithelium, resulting in an inflammatory and wound healing response. In addition, we outline colonoscopy procedures to monitor the onset of disease in individual live mice.
- Publisher
- Humana Press
- Research Division(s)
- Inflammation
- PubMed ID
- 29322404
- Publisher's Version
- https://doi.org/10.1007/978-1-4939-7568-6_1
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-02-27 12:35:00
Last Modified: 2018-03-27 09:58:22