Characterization of Blimp-1 function in effector regulatory T cells
- Cretney, E; Leung, PS; Trezise, S; Newman, DM; Rankin, LC; Teh, CE; Putoczki, TL; Gray, DH; Belz, GT; Mielke, LA; Dias, S; Nutt, SL;
- Journal Title
- Journal of Autoimmunity
- Publication Type
- Journal Article
- Regulatory T (Treg) cells maintain immunological tolerance in steady-state and after immune challenge. Activated Treg cells can undergo further differentiation into an effector state that highly express genes critical for Treg cell function, including ICOS, TIGIT and IL-10, although how this process is controlled is poorly understood. Effector Treg cells also specifically express the transcriptional regulator Blimp-1 whose expression overlaps with many of the canonical markers associated with effector Treg cells, although not all ICOS(+)TIGIT(+) Treg cells express Blimp-1 or IL-10. In this study, we addressed the role of Blimp-1 in effector Treg cell function. Mice lacking Blimp-1 specifically in Treg cells mature normally, but succumb to a multi-organ inflammatory disease later in life. Blimp-1 is not required for Treg cell differentiation, with mutant mice having increased numbers of effector Treg cells, but regulated a suite of genes involved in cell signaling, communication and survival, as well as being essential for the expression of the immune modulatory cytokine IL-10. Thus, Blimp-1 is a marker of effector Treg cells in all contexts examined and is required for the full functionality of these cells during aging.
- WEHI Research Division(s)
- Inflammation; Molecular Immunology; Infection And Immunity; Cell Signalling And Cell Death; Molecular Genetics Of Cancer
- PubMed ID
- Publisher's Version
- Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-05-18 09:33:22Last Modified: 2019-12-03 03:43:20