Characterization of Blimp-1 function in effector regulatory T cells
Journal Title
Journal of Autoimmunity
Publication Type
Journal Article
Abstract
Regulatory T (Treg) cells maintain immunological tolerance in steady-state and after immune challenge. Activated Treg cells can undergo further differentiation into an effector state that highly express genes critical for Treg cell function, including ICOS, TIGIT and IL-10, although how this process is controlled is poorly understood. Effector Treg cells also specifically express the transcriptional regulator Blimp-1 whose expression overlaps with many of the canonical markers associated with effector Treg cells, although not all ICOS(+)TIGIT(+) Treg cells express Blimp-1 or IL-10. In this study, we addressed the role of Blimp-1 in effector Treg cell function. Mice lacking Blimp-1 specifically in Treg cells mature normally, but succumb to a multi-organ inflammatory disease later in life. Blimp-1 is not required for Treg cell differentiation, with mutant mice having increased numbers of effector Treg cells, but regulated a suite of genes involved in cell signaling, communication and survival, as well as being essential for the expression of the immune modulatory cytokine IL-10. Thus, Blimp-1 is a marker of effector Treg cells in all contexts examined and is required for the full functionality of these cells during aging.
Publisher
Elsevier
WEHI Research Division(s)
Inflammation; Molecular Immunology; Infection And Immunity; Cell Signalling And Cell Death; Molecular Genetics Of Cancer
PubMed ID
29724515
NHMRC Grants
NHMRC/1054925 NHMRC/1047313 NHMRC/1078763
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2018-05-18 09:33:22
Last Modified: 2019-12-03 03:43:20
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