Increasingly inbred and fragmented populations of Plasmodium vivax associated with the eastward decline in malaria transmission across the Southwest Pacific
Details
Publication Year 2018-01-26, Volume 12, Issue #1, Page e0006146
Journal Title
PLoS Neglected Tropical Diseases
Publication Type
Journal Article in press
Abstract
The human malaria parasite Plasmodium vivax is more resistant to malaria control strategies than Plasmodium falciparum, and maintains high genetic diversity even when transmission is low. To investigate whether declining P. vivax transmission leads to increasing population structure that would facilitate elimination, we genotyped samples from across the Southwest Pacific region, which experiences an eastward decline in malaria transmission, as well as samples from two time points at one site (Tetere, Solomon Islands) during intensified malaria control. Analysis of 887 P. vivax microsatellite haplotypes from hyperendemic Papua New Guinea (PNG, n = 443), meso-hyperendemic Solomon Islands (n = 420), and hypoendemic Vanuatu (n = 24) revealed increasing population structure and multilocus linkage disequilibrium yet a modest decline in diversity as transmission decreases over space and time. In Solomon Islands, which has had sustained control efforts for 20 years, and Vanuatu, which has experienced sustained low transmission for many years, significant population structure was observed at different spatial scales. We conclude that control efforts will eventually impact P. vivax population structure and with sustained pressure, populations may eventually fragment into a limited number of clustered foci that could be targeted for elimination.
Publisher
PLOS
WEHI Research Division(s)
Population Health And Immunity
PubMed ID
29373596
Open Access at Publisher's Site
https://doi.org/10.1371/journal.pntd.0006146
NHMRC Grants
NHMRC/1021544 NHMRC/1003825 NHMRC/1043345
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2018-03-27 09:20:20
Last Modified: 2018-03-27 09:38:09
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