The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infection
Details
Publication Year 2018-04-24,Volume 23,Issue #4,Page 1085-1098
Journal Title
Cell Reports
Publication Type
Journal Article
Abstract
Inflammasomes promote immunity to microbial pathogens by regulating the function of IL-1-family cytokines such as IL-18 and IL-1beta. However, the roles for inflammasomes during parasitic helminth infections remain unclear. We demonstrate that mice and humans infected with gastrointestinal nematodes display increased IL-18 secretion, which in Trichuris-infected or worm antigen-treated mice and in macrophages co-cultured with Trichuris antigens or exosome-like vesicles was dependent on the NLRP3 inflammasome. NLRP3-deficient mice displayed reduced pro-inflammatory type 1 cytokine responses and augmented protective type 2 immunity, which was reversed by IL-18 administration. NLRP3-dependent suppression of immunity partially required CD4(+) cells but was apparent even in Rag1(-/-) mice that lack adaptive immune cells, suggesting that NLRP3 influences both innate and adaptive immunity. These data highlight a role for NLRP3 in limiting protective immunity to helminths, suggesting that targeting the NLRP3 inflammasome may be an approach for limiting the disease burden associated with helminth infections.
Publisher
Cell Press
Research Division(s)
Inflammation
PubMed ID
29694887
Open Access at Publisher's Site
https://doi.org/10.1016/j.celrep.2018.03.097
NHMRC Grants
NHMRC/1099262
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2018-05-18 09:33:20
Last Modified: 2018-06-27 09:43:32
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