SOCS-mediated immunomodulation of natural killer cells
Journal Title
Cytokine
Publication Type
Journal Article in press
Abstract
Natural killer (NK) cells are innate immune cells with an intrinsic ability to detect and kill infected and cancerous cells. The success of therapies targeting immune checkpoints on CD8 cells has intensified interest in harnessing the cytolytic effector functions of NK cells for new cancer treatments. NK cell development, survival and effector activity is dependent on exposure to the cytokine interleukin (IL)-15. The suppressor of cytokine (SOCS) proteins (CIS; SOCS1-7) are important negative regulators of cytokine signaling, and both CIS and SOCS2 are reported to have roles in regulating NK cell responses. Their immunomodulatory effects on NK cells suggest that these SOCS proteins are promising targets that can potentially form the basis of novel cancer therapies. Here we discuss the role of NK cells in tumor immunity as well as review the role of the SOCS proteins in regulating IL-15 signaling and NK cell function.
Publisher
Elsevier
Research Division(s)
Inflammation
PubMed ID
29609875
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2018-04-11 08:53:36
Last Modified: 2018-04-11 09:21:45
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