Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation
- Author(s)
- Infantino, S; Light, A; O'Donnell, K; Bryant, V; Avery, DT; ELLIOTT, M; Tangye, SG; Belz, G; Mackay, F; Richard, S; Tarlinton, D;
- Details
- Publication Year 2017-10-12,Volume 8,Issue #1,Page 891
- Journal Title
- Naure Communications
- Publication Type
- Journal Article
- Abstract
- Arginine methylation catalyzed by protein arginine methyltransferases (PRMT) is a common post-translational modification in mammalian cells, regulating many important functions including cell signalling, proliferation and differentiation. Here we show the role of PRMT1 in B-cell activation and differentiation. PRMT1 expression and activity in human and mouse peripheral B cells increases in response to in vitro or in vivo activation. Deletion of the Prmt1 gene in mature B cells establishes that although the frequency and phenotype of peripheral B cell subsets seem unaffected, immune responses to T-cell-dependent and -independent antigens are substantially reduced. In vitro activation of Prmt1-deficient B cells with a variety of mitogens results in diminished proliferation, differentiation and survival, effects that are correlated with altered signal transduction from the B cell receptor. Thus PRMT1 activity in B cells is required for correct execution of multiple processes that in turn are necessary for humoral immunity.PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.
- Publisher
- Springer Nature
- Research Division(s)
- Immunology; Molecular Immunology
- PubMed ID
- 29026071
- Publisher's Version
- https://doi.org/10.1038/s41467-017-01009-1
- NHMRC Grants
- NHMRC/1054925,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-10-16 01:59:58
Last Modified: 2017-10-16 02:58:46