Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development
Journal Title
Elife
Publication Type
Journal Article
Abstract
The study of antigenic targets of naturally-acquired immunity is essential to identify and prioritize antigens for further functional characterization. We measured total IgG antibodies to 38 P. vivax antigens, investigating their relationship with prospective risk of malaria in a cohort of 1-3 years old Papua New Guinean children. Using simulated annealing algorithms, the potential protective efficacy of antibodies to multiple antigen-combinations, and the antibody thresholds associated with protection were investigated for the first time. High antibody levels to multiple known and newly identified proteins were strongly associated with protection (IRR 0.44-0.74, P<0.001-0.041). Among five-antigen combinations with the strongest protective effect (>90%), EBP, DBPII, RBP1a, CyRPA, and PVX_081550 were most frequently identified; several of them requiring very low antibody levels to show a protective association. These data identify individual antigens that should be prioritized for further functional testing and establish a clear path to testing a multicomponent P. vivax vaccine.
Publisher
eLIFE
WEHI Research Division(s)
Infection And Immunity; Population Health And Immunity
PubMed ID
28949293
Open Access at Publisher's Site
https://elifesciences.org/articles/28673
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2017-10-16 01:59:57
Last Modified: 2017-10-16 02:55:54
An error has occurred. This application may no longer respond until reloaded. Reload 🗙