SIDT2 transports extracellular dsRNA into the cytoplasm for innate immune recognition

Nguyen, TA; Smith, BRC; Tate, MD; Belz, GT; Barrios, MH; Elgass, KD; Weisman, AS; Baker, PJ; Preston, SP; Whitehead, L; Garnham, A; Lundie, RJ; Smyth, GK; Pellegrini, M; O&#39;Keeffe, M; Wicks, IP; Masters, SL; Hunter, CP; Pang, KC

Author(s): Nguyen, TA; Smith, BRC; Tate, MD; Belz, GT; Barrios, MH; Elgass, KD; Weisman, AS; Baker, PJ; Preston, SP; Whitehead, L; Garnham, A; Lundie, RJ; Smyth, GK; Pellegrini, M; O'Keeffe, M; Wicks, IP; Masters, SL; Hunter, CP; Pang, KC;
Details: Publication Year 2017-09-19,Volume 47,Issue #3,Page 498-509.e6
Journal Title: Immunity
Publication Type: Journal Article
Abstract: Double-stranded RNA (dsRNA) is a common by-product of viral infections and acts as a potent trigger of antiviral immunity. In the nematode C. elegans, sid-1 encodes a dsRNA transporter that is highly conserved throughout animal evolution, but the physiological role of SID-1 and its orthologs remains unclear. Here, we show that the mammalian SID-1 ortholog, SIDT2, is required to transport internalized extracellular dsRNA from endocytic compartments into the cytoplasm for immune activation. Sidt2-deficient mice exposed to extracellular dsRNA, encephalomyocarditis virus (EMCV), and herpes simplex virus 1 (HSV-1) show impaired production of antiviral cytokines and-in the case of EMCV and HSV-1-reduced survival. Thus, SIDT2 has retained the dsRNA transport activity of its C. elegans ortholog, and this transport is important for antiviral immunity.
Publisher: Cell Press
Research Division(s): Inflammation; Molecular Immunology; Systems Biology And Personalised Medicine; Bioinformatics; Infection And Immunity
PubMed ID: 28916264
Publisher's Version: https://doi.org/10.1016/j.immuni.2017.08.007
NHMRC Grants: NHMRC/1006592, NHMRC/1045549, NHMRC/106562,
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2017-10-16 02:00:12

Last Modified: 2017-10-16 04:53:11