SIDT2 transports extracellular dsRNA into the cytoplasm for innate immune recognition
Details
Publication Year 2017-09-19, Volume 47, Issue #3, Page 498-509.e6
Journal Title
Immunity
Publication Type
Journal Article
Abstract
Double-stranded RNA (dsRNA) is a common by-product of viral infections and acts as a potent trigger of antiviral immunity. In the nematode C. elegans, sid-1 encodes a dsRNA transporter that is highly conserved throughout animal evolution, but the physiological role of SID-1 and its orthologs remains unclear. Here, we show that the mammalian SID-1 ortholog, SIDT2, is required to transport internalized extracellular dsRNA from endocytic compartments into the cytoplasm for immune activation. Sidt2-deficient mice exposed to extracellular dsRNA, encephalomyocarditis virus (EMCV), and herpes simplex virus 1 (HSV-1) show impaired production of antiviral cytokines and-in the case of EMCV and HSV-1-reduced survival. Thus, SIDT2 has retained the dsRNA transport activity of its C. elegans ortholog, and this transport is important for antiviral immunity.
Publisher
Cell Press
WEHI Research Division(s)
Inflammation; Molecular Immunology; Systems Biology And Personalised Medicine; Bioinformatics; Infection And Immunity
PubMed ID
28916264
NHMRC Grants
NHMRC/1006592 NHMRC/1045549 NHMRC/106562
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2017-10-16 02:00:12
Last Modified: 2017-10-16 04:53:11
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