SIDT2 transports extracellular dsRNA into the cytoplasm for innate immune recognition
- Nguyen, TA; Smith, BRC; Tate, MD; Belz, GT; Barrios, MH; Elgass, KD; Weisman, AS; Baker, PJ; Preston, SP; Whitehead, L; Garnham, A; Lundie, RJ; Smyth, GK; Pellegrini, M; O'Keeffe, M; Wicks, IP; Masters, SL; Hunter, CP; Pang, KC;
Publication Year 2017-09-19, Volume 47, Issue #3, Page 498-509.e6
- Journal Title
- Publication Type
- Journal Article
- Double-stranded RNA (dsRNA) is a common by-product of viral infections and acts as a potent trigger of antiviral immunity. In the nematode C. elegans, sid-1 encodes a dsRNA transporter that is highly conserved throughout animal evolution, but the physiological role of SID-1 and its orthologs remains unclear. Here, we show that the mammalian SID-1 ortholog, SIDT2, is required to transport internalized extracellular dsRNA from endocytic compartments into the cytoplasm for immune activation. Sidt2-deficient mice exposed to extracellular dsRNA, encephalomyocarditis virus (EMCV), and herpes simplex virus 1 (HSV-1) show impaired production of antiviral cytokines and-in the case of EMCV and HSV-1-reduced survival. Thus, SIDT2 has retained the dsRNA transport activity of its C. elegans ortholog, and this transport is important for antiviral immunity.
- Cell Press
- WEHI Research Division(s)
- Inflammation; Molecular Immunology; Systems Biology And Personalised Medicine; Bioinformatics; Infection And Immunity
- PubMed ID
- Publisher's Version
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Creation Date: 2017-10-16 02:00:12Last Modified: 2017-10-16 04:53:11