Role of the beta Common (betac) family of cytokines in health and disease
Journal Title
Cold Spring Harbor Perspectives in Biology
Publication Type
Journal Article in press
Abstract
The beta common ([betac]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use betac as their key signaling receptor subunit. This is a prototypic signaling subunit-sharing cytokine family that has unveiled many biological paradigms and structural principles applicable to the IL-2, IL-4, and IL-6 receptor families, all of which also share one or more signaling subunits. Originally identified for their functions in the hematopoietic system, the betac cytokines are now known to be truly pleiotropic, impacting on multiple cell types, organs, and biological systems, and thereby controlling the balance between health and disease. This review will focus on the emerging biological roles for the betac cytokines, our progress toward understanding the mechanisms of receptor assembly and signaling, and the application of this knowledge to develop exciting new therapeutic approaches against human disease.
Publisher
CSHLP
WEHI Research Division(s)
Systems Biology And Personalised Medicine
PubMed ID
28716883
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2017-08-30 02:22:42
Last Modified: 2017-09-05 08:43:06
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