Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria
- Author(s)
- Milicic, A; SRollier C; Tang, CK; Longley, R; Hill, AVS; Reyes-Sandoval, A;
- Details
- Publication Year 2017-08-04,Volume 7,Issue #1,Page 7284
- Journal Title
- Scientific Reports
- Publication Type
- Journal Article
- Abstract
- The majority of routinely given vaccines require two or three immunisations for full protective efficacy. Single dose vaccination has long been considered a key solution to improving the global immunisation coverage. Recent infectious disease outbreaks have further highlighted the need for vaccines that can achieve full efficacy after a single administration. Viral vectors are a potent immunisation platform, benefiting from intrinsic immuno-stimulatory features while retaining excellent safety profile through the use of non-replicating viruses. We investigated the scope for enhancing the protective efficacy of a single dose adenovirus-vectored malaria vaccine in a mouse model of malaria by co-administering it with vaccine adjuvants. Out of 11 adjuvants, only two, Abisco(R)-100 and CoVaccineHTTM, enhanced vaccine efficacy and sterile protection following malaria challenge. The CoVaccineHTTM adjuvanted vaccine induced significantly higher proportion of antigen specific central memory CD8+ cells, and both adjuvants resulted in increased proportion of CD8+ T cells expressing the CD107a degranulation marker in the absence of IFNgamma, TNFalpha and IL2 production. Our results show that the efficacy of vaccines designed to induce protective T cell responses can be positively modulated with chemical adjuvants and open the possibility of achieving full protection with a single dose immunisation.
- Publisher
- Springer Nature
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 28779101
- Publisher's Version
- https://doi.org/10.1038/s41598-017-07246-0
- Open Access at Publisher's Site
http://www.nature.com/articles/s41598-017-07246-0- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-08-30 02:22:30
Last Modified: 2017-09-04 03:05:00