Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions
Details
Publication Year 2017-09-11, Volume 11, Issue #9, Page e0005888
Journal Title
PLoS Neglected Tropical Diseases
Publication Type
Journal Article
Abstract
Plasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific. Naturally acquired antibody responses against multiple P. vivax proteins have been described in numerous countries, however, direct comparison of these responses has been difficult with different methodologies employed. We measured antibody responses against 307 P. vivax proteins at the time of P. vivax infection, and at 2-3 later time-points in three countries. We observed that seropositivity rates at the time of infection were highest in Thailand, followed by Brazil then PNG, reflecting the level of antigenic input. The majority of sero-reactive antigens in all sites induced short-lived antibody responses with estimated half-lives of less than 6 months, although there was a trend towards longer-lived responses in PNG children. Despite these differences, IgG seropositivity rates, magnitude and longevity were highly and significantly rank-correlated between the different regions, suggesting such features are reflective of the individual protein.
Publisher
PLOS
WEHI Research Division(s)
Population Health And Immunity
PubMed ID
28892517
NHMRC Grants
NHMRC/1021544 NHMRC/1043345 NHMRC/1016443
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2017-09-18 11:59:38
Last Modified: 2017-09-18 12:14:13
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