Regulation of Megakaryocyte and Platelet Survival
- Author(s)
- Au, Amanda E; Lebois, Marion; Pleines, Irina; Josefsson, Emma C;
- Journal Title
- Molecular and Cellular Biology of Platelet Formation: Implications in Health and Disease
- Publication Type
- Book Section
- Abstract
- Platelets play vital roles in hemostasis, wound healing, and a range of other processes [1]. Their number is tightly controlled within narrow physiological ranges. This occurs through a dynamic balance between platelet production and consumption/clearance rates, so as to ensure that the total platelet mass remains constant. Megakaryocytes in the bone marrow produce around 100 billion platelets per day. In a healthy individual, the majority of platelets are not consumed by hemostatic processes. It is therefore imperative that platelet lifespan is strictly regulated. Recent work has demonstrated that the survival of megakaryocytes and platelets is controlled by programmed cell death, apoptosis [2]. Both cell types possess a classical Bak- and Bax-mediated intrinsic, mitochondrial, apoptosis pathway that must be restrained in order for them to develop and survive. In addition, recent work has revealed that the glycosylation state of platelet surface proteins is an indicator of platelet age and that aged, desialylated platelets stimulate platelet production [3].
- Publisher
- Springer International Publishing
- Research Division(s)
- Chemical Biology; Cancer And Haematology
- Publisher's Version
- https://doi.org/10.1007/978-3-319-39562-3_9
- NHMRC Grants
- NHMRC/1079250, NHMRC/1016647,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-09-18 11:59:35
Last Modified: 2017-09-18 12:09:42