Interleukin-11 classic but not trans-signaling is essential for fertility in mice
- Author(s)
- Agthe, M; Garbers, Y; Putoczki, T; Garbers, C;
- Journal Title
- Placenta
- Publication Type
- Journal Article
- Abstract
- The cytokine interleukin (IL)-11 activates its target cells through binding to the membrane-bound IL-11 receptor (IL-11R). Female mice deficient in IL-11R (Il11ra-/-) are infertile due to a defect in decidualization when the blastocyst implants. We have recently shown that IL-11 can also signal via a soluble IL-11R (trans-signaling). Which IL-11 pathway is required for fertility in mice is unknown. We confirm that female Il11ra-/-mice, lacking both classic and trans-signaling, are infertile. In contrast, the selective blockade of IL-11 trans-signaling does not affect fertility in mice. These results show that classic, but not trans-signaling of IL-11, is essential for fertility in mice.
- Publisher
- Elsevier
- Research Division(s)
- Inflammation
- PubMed ID
- 28864002
- Publisher's Version
- https://doi.org/10.1016/j.placenta.2017.05.015
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-09-06 11:18:15
Last Modified: 2017-09-06 01:23:15