Emerging concepts in innate immunity
- Author(s)
- Pelka, K; De Nardo, D;
- Journal Title
- Innate Immune Activation. Methods in Molecular Biology, vol 1714
- Publication Type
- Book Section
- Abstract
- This review introduces recent concepts in innate immunity highlighting some of the latest exciting findings. These include: the discovery of the initiator of pyroptosis, Gasdermin D, and mechanisms of inflammatory caspases in innate immune signaling; the formation of oligomeric signalosomes downstream of innate immune receptors; mechanisms that shape innate immune responses, such as cellular homeostasis, cell metabolism, and pathogen viability; rapid methods of cell-to-cell communication; the interplay between the host and its microbiome and the concept of innate immunological memory. Furthermore, we discuss open questions and illustrate how technological advances, such as CRISPR/Cas9, may provide important answers for outstanding questions in the field of innate immunity.
- Publisher
- Humana Press Inc.
- Research Division(s)
- Inflammation
- PubMed ID
- 29177852
- Publisher's Version
- https://doi.org/10.1007/978-1-4939-7519-8_1
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-01-15 09:30:06
Last Modified: 2018-02-14 03:53:36