Cross-talk between protein synthesis, energy metabolism and autophagy in cancer
Journal Title
Curr Opin Genet Dev
Publication Type
Journal Article
Abstract
Translation is a pivotal step in the regulation of gene expression as well as one of the most energy consuming processes in the cell. Dysregulation of translation caused by the aberrant function of upstream signaling pathways and/or perturbations in the expression or function of components of the translation machinery is frequent in cancer. In this review, we discuss emerging findings that highlight hitherto unappreciated aspects of signaling to the translation apparatus with the particular focus on emerging connections between protein synthesis, autophagy and energy homeostasis in cancer.
Publisher
Elsevier
WEHI Research Division(s)
Cell Signalling And Cell Death
PubMed ID
29179096
Open Access at Publisher's Site
https://doi.org/10.1016/j.gde.2017.11.003
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2018-01-15 09:30:04
Last Modified: 2018-01-15 09:51:36
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