Detection and quantification of MAVS aggregation via confocal microscopy
- Author(s)
- Nguyen, TA; Whitehead, L; Pang, KC;
- Journal Title
- Methods Mol Biol
- Publication Type
- Journal Article
- Abstract
- During infection, the cytosolic detection of viral double-stranded RNA (dsRNA) leads to the oligomerization and activation of mitochondrial antiviral signaling protein (MAVS) and the subsequent production of type I interferon (IFN). Here, we describe a novel method of visualizing and quantifying the aggregation of MAVS in response to dsRNA stimulation or viral infection in vitro using confocal microscopy.
- Publisher
- Humana Press Inc.
- Research Division(s)
- Inflammation
- PubMed ID
- 29177867
- Publisher's Version
- https://doi.org/10.1007/978-1-4939-7519-8_16
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-01-15 09:30:08
Last Modified: 2018-02-14 03:51:35