Interleukin-7
- Author(s)
- Pellegrini, Marc; Ohashi, Pamela;
- Journal Title
- Cancer Therapeutic Targets
- Publication Type
- Book Section
- Abstract
- IL-7 and its cognate receptor are critical for normal development, function and maintenance of the immune system. Aberrant and excessive activation of the IL-7 signalling pathway can promote certain hematological malignancies. It is not clear if a potential therapeutic that targets and antagonizes IL-7 signalling would have efficacy as an anti-cancer agent for maligancies where this signalling pathway is abnormally activated. Conversely enhancing IL-7 signalling, through administration of exogenous IL-7 cytokine, may have an adjuvant therapuetic benefit in promoting the efficacy of other immune based therapies used to treat malignancies such as melanoma. It is unclear if prolonged use of exogenously administered IL-7 results in any adverse outcomes.
- Publisher
- Springer New York
- Research Division(s)
- Infection And Immunity
- Publisher's Version
- https://doi.org/10.1007/978-1-4419-0717-2_45
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-01-15 12:39:50
Last Modified: 2018-01-15 12:48:02