Thymospheres are formed by mesenchymal cells with the potential to generate adipocytes, but not epithelial cells
Details
Publication Year 2017-10-24, Volume 21, Issue #4, Page 934-942
Journal Title
Cell Reports
Publication Type
Journal Article
Abstract
Evidence suggests that a stem-cell-driven differentiation hierarchy maintains the dynamic thymic epithelial cell (TEC) network that governs T lymphocyte development. The identification of TEC stem/progenitor cells has been a major focus in the field, and several candidates with contrasting phenotypes have been described. We sought to determine the provenance and function of the only population reported to exhibit TEC stem cell properties in the adult, a Foxn1- EpCAM- cell that generates so-called thymospheres. We provide evidence that the thymosphere-forming cell (TSFC) is not a TEC stem cell but can incorporate bystander TECs into thymospheres, providing an explanation for the epithelial activity ascribed to these structures. TSFCs were found to share a phenotype, transcriptional profile, and developmental origin with thymic fibroblasts and can generate adipocytes. In summary, this study redefines the nature of bipotent TEC stem/progenitor cells in the adult thymus and highlights a potentially important mesenchymal progenitor population.
Publisher
Cell Press
WEHI Research Division(s)
Molecular Genetics Of Cancer; Molecular Medicine
PubMed ID
29069601
Open Access at Publisher's Site
http://dx.doi.org/10.1016/j.celrep.2017.09.090
NHMRC Grants
NHMRC/1049724 NHMRC/1090236 NHMRC/1104924
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2017-11-16 04:56:12
Last Modified: 2017-11-17 12:52:10
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