Recent advances in understanding inhibitor of apoptosis proteins
Author(s)
Lalaoui, N; Vaux, DL;
Journal Title
F1000Research
Publication Type
Journal Article
Abstract
The inhibitor of apoptosis proteins (IAPs) are a family of proteins that were chiefly known for their ability to inhibit apoptosis by blocking caspase activation or activity. Recent research has shown that cellular IAP1 (cIAP1), cIAP2, and X-linked IAP (XIAP) also regulate signaling by receptors of the innate immune system by ubiquitylating their substrates. These IAPs thereby act at the intersection of pathways leading to cell death and inflammation. Mutation of IAP genes can impair tissue homeostasis and is linked to several human diseases. Small-molecule IAP antagonists have been developed to treat certain malignant, infectious, and inflammatory diseases. Here, we will discuss recent advances in our understanding of the functions of cIAP1, cIAP2, and XIAP; the consequences of their mutation or dysregulation; and the therapeutic potential of IAP antagonist drugs.
Publisher
F1000
Research Division(s)
Cell Signalling And Cell Death
PubMed ID
30631429
Open Access at Publisher's Site
https://doi.org/10.12688/f1000research.16439.1
NHMRC Grants
NHMRC/1113133NHMRC/1020136
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-01-15 10:22:37
Last Modified: 2019-01-15 10:23:47
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