The Scalloped and Nerfin-1 transcription factors cooperate to maintain neuronal cell fate
- Author(s)
- Vissers, JHA; Froldi, F; Schroder, J; Papenfuss, AT; Cheng, LY; Harvey, KF;
- Details
- Publication Year 2018-11-06,Volume 25,Issue #6,Page 1561-1576 e7
- Journal Title
- Cell Reports
- Publication Type
- Journal Article
- Abstract
- The ability of cells to stably maintain their fate is governed by specific transcription regulators. Here, we show that the Scalloped (Sd) and Nervous fingers-1 (Nerfin-1) transcription factors physically and functionally interact to maintain medulla neuron fate in the Drosophila melanogaster CNS. Using Targeted DamID, we find that Sd and Nerfin-1 occupy a highly overlapping set of target genes, including regulators of neural stem cell and neuron fate, and signaling pathways that regulate CNS development such as Notch and Hippo. Modulation of either Sd or Nerfin-1 activity causes medulla neurons to dedifferentiate to a stem cell-like state, and this is mediated at least in part by Notch pathway deregulation. Intriguingly, orthologs of Sd and Nerfin-1 have also been implicated in control of neuronal cell fate decisions in both worms and mammals. Our data indicate that this transcription factor pair exhibits remarkable biochemical and functional conservation across metazoans.
- Publisher
- Elsevier
- Research Division(s)
- Bioinformatics
- PubMed ID
- 30404010
- Publisher's Version
- https://doi.org/10.1016/j.celrep.2018.10.038
- Open Access at Publisher's Site
https://doi.org/10.1016/j.celrep.2018.10.038- NHMRC Grants
- NHMRC/1054618,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-11-20 09:12:54
Last Modified: 2018-11-20 01:13:34