The structural basis of necroptotic cell death signaling
- Author(s)
- Petrie, EJ; Czabotar, PE; Murphy, JM;
- Journal Title
- Trends Biochem Sci
- Publication Type
- Journal Article in press
- Abstract
- The recent implication of the cell death pathway, necroptosis, in innate immunity and a range of human pathologies has led to intense interest in the underlying molecular mechanism. Unlike the better-understood apoptosis pathway, necroptosis is a caspase-independent pathway that leads to cell lysis and release of immunogens downstream of death receptor and Toll-like receptor (TLR) ligation. Here we review the role of recent structural studies of the core machinery of the pathway, the protein kinases receptor-interacting protein kinase (RIPK)1 and RIPK3, and the terminal effector, the pseudokinase mixed lineage kinase domain-like protein (MLKL), in shaping our mechanistic understanding of necroptotic signaling. Structural studies have played a key role in establishing models that describe MLKL's transition from a dormant monomer to a killer oligomer and revealing important interspecies differences.
- Publisher
- Cell Press
- Research Division(s)
- Structural Biology; Cell Signalling And Cell Death
- PubMed ID
- 30509860
- Publisher's Version
- https://doi.org/10.1016/j.tibs.2018.11.002
- NHMRC Grants
- NHMRC/1079700, NHMRC/1105754, NHMRC/1124735, NHMRC/1124737,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-12-18 02:54:30
Last Modified: 2018-12-18 04:17:08