Frequent activating STAT3 mutations and novel recurrent genomic abnormalities detected in breast implant-associated anaplastic large cell lymphoma
Details
Publication Year 2018-11-16, Volume 9, Issue #90, Page 36126-36136
Journal Title
Oncotarget
Publication Type
Journal Article
Abstract
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare form of T-cell lymphoma that occurs after implantation of breast prostheses. We performed comprehensive next generation sequencing based genomic characterization of 11 cases of BIA-ALCL including sequence variant detection on 180 genes frequently mutated in haematological malignancy, genome-wide copy number assessment, structural variant detection involving the T-cell receptor loci and TRB deep-sequencing. We observed sequence variants leading to JAK/STAT activation in 10 out of 11 patients. We also observed germline TP53 mutations in two cases. In addition we detected a recurrent copy number loss involving RPL5 as well as copy number amplifications involving TNFRSF11A [RANK] (in 2 cases), MYC, P2RX7, TMEM119 and PDGFRA. In summary, our comprehensive genomic characterisation of 11 cases of BIA-ALCL has provided insight into potential pathobiological mechanisms (JAK/STAT, MYC and TP53) as well as identifying targets for future therapeutic intervention (TNFRSF11A, PDGFRA) in this rare entity.
Publisher
Impact Journals LLC
WEHI Research Division(s)
Stem Cells And Cancer
PubMed ID
30546832
Open Access at Publisher's Site
https://doi.org/10.18632/oncotarget.26308
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-01-15 08:46:08
Last Modified: 2019-01-15 08:46:56
An error has occurred. This application may no longer respond until reloaded. Reload 🗙