The inner ear proteome of fish
- Author(s)
- Thomas, ORB; Swearer, SE; Kapp, EA; Peng, P; Tonkin-Hill, GQ; Papenfuss, A; Roberts, A; Bernard, P; Roberts, BR;
- Journal Title
- FEBS Journal
- Publication Type
- Journal Article in press
- Abstract
- The mechanisms that underpin the formation, growth and composition of otoliths, the biomineralized stones in the inner ear of fish, are largely unknown, as only a few fish inner ear proteins have been reported. Using a partial transcriptome for the inner ear of black bream (Acanthopagrus butcheri), in conjunction with proteomic data, we discovered hundreds of previously unknown proteins in the otolith. This allowed us to develop hypotheses to explain the mechanisms of inorganic material supply and daily formation of growth bands. We further identified a likely protein mediator of crystal nucleation and an explanation for the apparent metabolic inertness of the otolith. Due to the formation of both daily and annual increments, otoliths are routinely employed as natural chronometers, being used for age and growth estimation, fisheries stock assessments, and the reconstruction of habitat use, movement, diet, and the impacts of climate change. Our findings provide an unprecedented view of otolith molecular machinery, aiding in the interpretation of these essential archived data. This article is protected by copyright. All rights reserved.
- Publisher
- Wiley
- Research Division(s)
- Systems Biology And Personalised Medicine; Bioinformatics
- PubMed ID
- 30521091
- Publisher's Version
- https://doi.org/10.1111/febs.14715
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-12-18 02:54:31
Last Modified: 2018-12-18 04:13:25