Tasmanian devils with contagious cancer exhibit a constricted T-cell repertoire diversity
Journal Title
Communications Biology
Publication Type
Journal Article
Abstract
The Tasmanian devil (Sarcophilus harrisii) is threatened by a contagious cancer, known as Devil Facial Tumour Disease (DFTD). A highly diverse T-cell receptor (TCR) repertoire is crucial for successful host defence against cancers. By investigating TCR beta chain diversity in devils of different ages, we show that the T-cell repertoire in devils constricts in their second year of life, which may explain the higher DFTD prevalence in older devils. Unexpectedly, we also observed a pronounced decline in TCR diversity and T cell clonal expansion in devils after DFTD infection. These findings overturned the previous assumption that DFTD did not directly impact host immunity.
Publisher
Springer
WEHI Research Division(s)
Bioinformatics
PubMed ID
30886908
Open Access at Publisher's Site
https://doi.org/10.1038/s42003-019-0342-5
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-03-27 08:18:48
Last Modified: 2019-03-27 08:41:57
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