Comprehensive synthesis of substrates, Iintermediates, and products of the sulfoglycolytic Embden-Meyerhoff-Parnas pathway
Details
Publication Year 2019-03-01, Volume 84, Issue #5, Page 2901-2910
Journal Title
Journal of Organic Chemistry
Publication Type
Journal Article
Abstract
Sulfoglycolysis is a metabolic pathway dedicated to the catabolism of the sulfosugar sulfoquinovose (SQ) into smaller organosulfur fragments. An estimated 10 billion tonnes of SQ fluxes through sulfoglycolysis pathways each year, making it a significant aspect of the biogeochemical sulfur cycle. Delineating the molecular details of sulfoglycolysis requires authentic samples of the various metabolites in these pathways. To this end, we have established chemical and chemoenzymatic methods for the synthesis of the key organosulfur metabolites sulfoquinovosylglycerol, SQ (also in (13)C6-labeled form), sulfofructose, sulfofructose-1-phosphate, sulfolactaldehyde, and 2,3-dihydroxypropanesulfonate, as well as an improved route to the chromogenic sulfoquinovosidase substrate 4-nitrophenyl alpha-sulfoquinovoside.
Publisher
ACS
WEHI Research Division(s)
Chemical Biology
PubMed ID
30742766
NHMRC Grants
NHMRC/GNT1139549
ARC Grants
ARC/DP180101957,
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-03-27 08:18:47
Last Modified: 2020-02-11 02:26:35
An error has occurred. This application may no longer respond until reloaded. Reload 🗙