Comprehensive synthesis of substrates, Iintermediates, and products of the sulfoglycolytic Embden-Meyerhoff-Parnas pathway
- Author(s)
- Abayakoon, P; Epa, R; Petricevic, M; Bengt, C; Mui, JW; van der Peet, PL; Zhang, Y; Lingford, JP; White, JM; Goddard-Borger, ED; Williams, SJ;
- Details
- Publication Year 2019-03-01,Volume 84,Issue #5,Page 2901-2910
- Journal Title
- Journal of Organic Chemistry
- Publication Type
- Journal Article
- Abstract
- Sulfoglycolysis is a metabolic pathway dedicated to the catabolism of the sulfosugar sulfoquinovose (SQ) into smaller organosulfur fragments. An estimated 10 billion tonnes of SQ fluxes through sulfoglycolysis pathways each year, making it a significant aspect of the biogeochemical sulfur cycle. Delineating the molecular details of sulfoglycolysis requires authentic samples of the various metabolites in these pathways. To this end, we have established chemical and chemoenzymatic methods for the synthesis of the key organosulfur metabolites sulfoquinovosylglycerol, SQ (also in (13)C6-labeled form), sulfofructose, sulfofructose-1-phosphate, sulfolactaldehyde, and 2,3-dihydroxypropanesulfonate, as well as an improved route to the chromogenic sulfoquinovosidase substrate 4-nitrophenyl alpha-sulfoquinovoside.
- Publisher
- ACS
- Research Division(s)
- Chemical Biology
- PubMed ID
- 30742766
- Publisher's Version
- https://doi.org/10.1021/acs.joc.9b00055
- NHMRC Grants
- NHMRC/GNT1139549,
- ARC Grants
- ARC/DP180101957,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2019-03-27 08:18:47
Last Modified: 2020-02-11 02:26:35