Genome organization in immune cells: unique challenges
Details
Publication Year 2019-07, Volume 19, Issue #7, Page 448-456
Journal Title
Nature Reviews Immunology
Publication Type
Journal Article
Abstract
Each type of cell in the immune system performs critical functions to protect the body and maintain health. In order to fulfil these roles some immune cells rely on unique processes, including antigen receptor loci recombination, clonal expansion or the contortion of their nuclei. In turn, each of these processes relies on, or poses unique challenges to, a genome organized in three dimensions. Here, we explore the current understanding of the importance of 3D genome organization in the function and development of a healthy immune system.
Publisher
Springer Nature
WEHI Research Division(s)
Immunology
PubMed ID
30926914
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-04-11 12:23:45
Last Modified: 2019-07-25 11:33:19
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