Targets of complement-fixing antibodies in protective immunity against malaria in children
- Author(s)
- Reiling, L; Boyle, MJ; White, MT; Wilson, DW; Feng, G; Weaver, R; Opi, DH; Persson, KEM; Richards, JS; Siba, PM; Fowkes, FJI; Takashima, E; Tsuboi, T; Mueller, I; Beeson, JG;
- Details
- Publication Year 2019-02-05,Volume 10,Issue #1,Page 610
- Journal Title
- Nature Communications
- Publication Type
- Journal Article
- Abstract
- Antibodies against P. falciparum merozoites fix complement to inhibit blood-stage replication in naturally-acquired and vaccine-induced immunity; however, specific targets of these functional antibodies and their importance in protective immunity are unknown. Among malaria-exposed individuals, we show that complement-fixing antibodies to merozoites are more strongly correlated with protective immunity than antibodies that inhibit growth quantified using the current reference assay for merozoite vaccine evaluation. We identify merozoite targets of complement-fixing antibodies and identify antigen-specific complement-fixing antibodies that are strongly associated with protection from malaria in a longitudinal study of children. Using statistical modelling, combining three different antigens targeted by complement-fixing antibodies could increase the potential protective effect to over 95%, and we identify antigens that were common in the most protective combinations. Our findings support antibody-complement interactions against merozoite antigens as important anti-malaria immune mechanisms, and identify specific merozoite antigens for further evaluation as vaccine candidates.
- Publisher
- Springer Nature
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 30723225
- Publisher's Version
- https://doi.org/10.1038/s41467-019-08528-z
- Open Access at Publisher's Site
https://doi.org/10.1038/s41467-019-08528-z- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2019-03-13 08:04:18
Last Modified: 2019-04-01 08:42:30