Highly fluorescent and HDAC6 selective scriptaid analogues
Journal Title
European Journal of Medicinal Chemistry
Publication Type
Journal Article
Abstract
Fluorescent scriptaid analogues with excellent HDAC6 selectivity (HDAC1/6>500) and potency (HDAC6 IC50<5nM) have been synthesised and evaluated. The highly fluorescent nature of the compounds (up to PhiF=0.83 in DMSO and 0.38 in aqueous buffer) makes them ideally suited for cellular imaging and visualisation of their cytoplasmic localisation was readily accomplished. Whole organism imaging in zebrafish confirmed both the vascular localisation of the new inhibitors and the impact of HDAC6 inhibition on in vivo development.
Publisher
Elsevier
WEHI Research Division(s)
Chemical Biology
PubMed ID
30448419
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-03-13 08:04:16
Last Modified: 2019-03-13 08:46:06
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