Lack of protein prenylation promotes Nlrp3 inflammasome assembly in human monocytes
Journal Title
Journal of Allergy and Clinical Immunology
Publication Type
Journal Article in press
Abstract
We demonstrate that blocking the mevalonate pathway and protein prenylation in human monocytes leads to enhanced activity of an NLRP3-dependent, but not Pyrin-dependent, inflammasome, suggesting a prominent role for NLRP3 in the pathogenesis of mevalonate kinase deficiency.
Publisher
Elsevier
WEHI Research Division(s)
Inflammation
PubMed ID
30797829
Open Access at Publisher's Site
https://doi.org/10.1016/j.jaci.2019.02.013
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-03-13 11:54:06
Last Modified: 2019-03-13 02:25:06
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