Lack of protein prenylation promotes Nlrp3 inflammasome assembly in human monocytes
- Author(s)
- Skinner, OP; Jurczyluk, J; Baker, PJ; Masters, SL; Wilks, AR; Clearwater, MS; Robertson, AAB; Schroder, K; Mehr, S; Munoz, MA; Rogers, MJ;
- Journal Title
- Journal of Allergy and Clinical Immunology
- Publication Type
- Journal Article in press
- Abstract
- We demonstrate that blocking the mevalonate pathway and protein prenylation in human monocytes leads to enhanced activity of an NLRP3-dependent, but not Pyrin-dependent, inflammasome, suggesting a prominent role for NLRP3 in the pathogenesis of mevalonate kinase deficiency.
- Publisher
- Elsevier
- Research Division(s)
- Inflammation
- PubMed ID
- 30797829
- Publisher's Version
- https://doi.org/10.1016/j.jaci.2019.02.013
- Open Access at Publisher's Site
https://doi.org/10.1016/j.jaci.2019.02.013- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2019-03-13 11:54:06
Last Modified: 2019-03-13 02:25:06