Distinct gut virome profile of pregnant women with type 1 diabetes in the ENDIA study

Wook Kim, K; Allen, DW; Briese, T; Couper, JJ; Barry, SC; Colman, PG; Cotterill, AM; Davis, EA; Giles, LC; Harrison, LC; Harris, M; Haynes, A; Horton, JL; Isaacs, SR; Jain, K; Lipkin, WI; Morahan, G; Morbey, C; Pang, ICN; Papenfuss, AT; Penno, MAS; Sinnott, RO; Soldatos, G; Thomson, RL; Vuillermin, PJ; Wentworth, JM; Wilkins, MR; Rawlinson, WD; Craig, ME; ENDIA Study Group

Author(s): Wook Kim, K; Allen, DW; Briese, T; Couper, JJ; Barry, SC; Colman, PG; Cotterill, AM; Davis, EA; Giles, LC; Harrison, LC; Harris, M; Haynes, A; Horton, JL; Isaacs, SR; Jain, K; Lipkin, WI; Morahan, G; Morbey, C; Pang, ICN; Papenfuss, AT; Penno, MAS; Sinnott, RO; Soldatos, G; Thomson, RL; Vuillermin, PJ; Wentworth, JM; Wilkins, MR; Rawlinson, WD; Craig, ME; ENDIA Study Group;
Details: Publication Year 2019-02,Volume 6,Issue #2,Page ofz025
Journal Title: Open Forum Infectious Diseases
Publication Type: Journal Article
Abstract: Background: The importance of gut bacteria in human physiology, immune regulation, and disease pathogenesis is well established. In contrast, the composition and dynamics of the gut virome are largely unknown; particularly lacking are studies in pregnancy. We used comprehensive virome capture sequencing to characterize the gut virome of pregnant women with and without type 1 diabetes (T1D), longitudinally followed in the Environmental Determinants of Islet Autoimmunity study. Methods: In total, 61 pregnant women (35 with T1D and 26 without) from Australia were examined. Nucleic acid was extracted from serial fecal specimens obtained at prenatal visits, and viral genomes were sequenced by virome capture enrichment. The frequency, richness, and abundance of viruses were compared between women with and without T1D. Results: Two viruses were more prevalent in pregnant women with T1D: picobirnaviruses (odds ratio [OR], 4.2; 95% confidence interval [CI], 1.0-17.1; P = .046) and tobamoviruses (OR, 3.2; 95% CI, 1.1-9.3; P = .037). The abundance of 77 viruses significantly differed between the 2 maternal groups (>/=2-fold difference; P < .02), including 8 Enterovirus B types present at a higher abundance in women with T1D. Conclusions: These findings provide novel insight into the composition of the gut virome during pregnancy and demonstrate a distinct profile of viruses in women with T1D.
Publisher: Oxford Academic
Research Division(s): Population Health And Immunity; Bioinformatics
PubMed ID: 30815502
Publisher's Version: https://doi.org/10.1093/ofid/ofz025
Open Access at Publisher's Site: https://doi.org/10.1093/ofid/ofz025
NHMRC Grants: NHMRC/1045777, NHMRC/1044694,
Terms of Use/Rights Notice: Refer to copyright notice on published article.
Documents: Wook KK et al Open Forum Infect Dis_2019.pdf - (0.55MB, application/pdf)

Creation Date: 2019-03-13 11:54:01

Last Modified: 2019-04-01 08:42:50