Sensing of physiological regulators by innate lymphoid cells
Journal Title
Cellular & Molecular Immunology
Publication Type
Journal Article in press
Abstract
Maintenance of homeostasis and immune protection rely on the coordinated action of different physiological systems. Bidirectional communication between the immune system and physiological systems is required to sense and restore any disruption of equilibrium. Recent transcriptomic analyses of innate lymphoid cells (ILCs) from different tissues have revealed that ILCs express a large array of receptors involved in the recognition of neuropeptides, hormones and metabolic signals. ILCs rapidly secrete effector cytokines that are central in the development and activation of early immune responses, but they also constitutively secrete mediators that are important for tissue homeostasis. To achieve these functions effectively, ILCs integrate intrinsic and extrinsic signals that modulate their constitutive and induced activity. Disruption of the regulation of ILCs by physiological regulators leads to altered immune responses with harmful consequences for the organism. An understanding of these complex interactions between the immune system and physiological mediators is crucial to decipher the events leading to the protective versus pathological effects of these cells.
Publisher
Springer Nature
Research Division(s)
Immunology
PubMed ID
30842626
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-03-13 11:54:00
Last Modified: 2019-03-13 12:17:07
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