Menstrual fluid factors facilitate tissue repair: identification and functional action in endometrial and skin repair

Evans, J; Infusini, G; McGovern, J; Cuttle, L; Webb, A; Nebl, T; Milla, L; Kimble, R; Kempf, M; Andrews, CJ; Leavesley, D; Salamonsen, LA

Author(s): Evans, J; Infusini, G; McGovern, J; Cuttle, L; Webb, A; Nebl, T; Milla, L; Kimble, R; Kempf, M; Andrews, CJ; Leavesley, D; Salamonsen, LA;
Details: Publication Year 2019-01,Volume 33,Issue #1,Page 584-605
Journal Title: FASEB Journal
Publication Type: Journal Article
Abstract: Repair after damage is essential for tissue homeostasis. Postmenstrual endometrial repair is a cyclical manifestation of rapid, scar-free, tissue repair taking approximately 3-5 d. Skin repair after wounding is slower ( approximately 2 wk). In the case of chronic wounds, it takes months to years to restore integrity. Herein, the unique "rapid-repair" endometrial environment is translated to the "slower repair" skin environment. Menstrual fluid (MF), the milieu of postmenstrual endometrial repair, facilitates healing of endometrial and keratinocyte "wounds" in vitro, promoting cellular adhesion and migration, stimulates keratinocyte migration in an ex vivo human skin reconstruct model, and promotes re-epithelialization in an in vivo porcine wound model. Proteomic analysis of MF identified a large number of proteins: migration inhibitory factor, neutrophil gelatinase-associated lipocalin, follistatin like-1, chemokine ligand-20, and secretory leukocyte protease inhibitor were selected for further investigation. Functionally, they promote repair of endometrial and keratinocyte wounds by promoting migration. Translation of these and other MF factors into a migration-inducing treatment paradigm could provide novel treatments for tissue repair.-Evans, J., Infusini, G., McGovern, J., Cuttle, L., Webb, A., Nebl, T., Milla, L., Kimble, R., Kempf, M., Andrews, C. J., Leavesley, D., Salamonsen, L. A. Menstrual fluid factors facilitate tissue repair: identification and functional action in endometrial and skin repair.
Publisher: FASEB
Research Division(s): Systems Biology And Personalised Medicine
PubMed ID: 30036086
Publisher's Version: https://doi.org/10.1096/fj.201800086R
NHMRC Grants: NHMRC/1047756,
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2018-08-15 03:28:50

Last Modified: 2019-01-09 03:20:24