Mismatch repair deficiency assessment by immunohistochemistry: for Lynch syndrome screening and beyond
- Journal Title
- Future Oncology
- Publication Type
- Journal Article in press
- Abstract
- While mismatch repair (MMR) deficiency has been studied extensively, the assessment of MMR status in colorectal and other cancers remains highly relevant, particularly in light of recent data demonstrating that MMR deficiency is a strong predictor for treatment benefit with immune checkpoint inhibitors across multiple tumor types. In colorectal cancer, there is a growing consensus in support of routine MMR testing for Lynch syndrome screening, to inform prognosis and adjuvant chemotherapy use in early stage disease, and to predict response to immunotherapy in advanced disease. Here, we provide a review of the Ventana MMR Immunohistochemistry Panel, which was recently approved by the US FDA for use in Lynch syndrome screening.
- Publisher
- Future Medicine
- Research Division(s)
- Systems Biology And Personalised Medicine
- PubMed ID
- 30004261
- Publisher's Version
- https://doi.org/10.2217/fon-2018-0319
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-07-23 09:32:19
Last Modified: 2018-07-23 10:38:26