The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development
- Author(s)
- Santa-Cecilia, FV; Ferreira, DW; Guimaraes, RM; Cecilio, NT; Fonseca, MM; Lopes, AH; Davoli-Ferreira, M; Kusuda, R; Souza, GR; Nachbur, U; Alves-Filho, JC; Teixeira, MM; Zamboni, DS; Cunha, FQ; Cunha, TM;
- Journal Title
- Pain
- Publication Type
- Journal Article in press
- Abstract
- Neuropathic pain is one of the most important types of chronic pain. It is caused by neuronal damage. Clinical and experimental studies suggest a critical role for neuro-immune interactions in the development of neuropathic pain. Herein, we have shown that the cytoplasmic receptor Nod-like receptor-2, NOD2, and its adaptor-signaling molecule RIPK2, participate in the development of neuropathic pain after peripheral nerve injury (Spared nerve injury model). The activation of NOD2 signaling in peripheral macrophage mediates the development of neuropathic pain through the production of pro-nociceptive cytokines (TNF and IL-1beta). This study found that peripheral nerve injury promoted a systemic increase in the NOD2 ligand. These results highlight a previously undetermined role for NOD2 signaling in the development of neuropathic pain, suggesting a new potential target for preventing neuropathic pain.
- Publisher
- Wolters Kluwer
- Research Division(s)
- Cell Signalling And Cell Death
- PubMed ID
- 30169421
- Publisher's Version
- https://doi.org/10.1097/j.pain.0000000000001383
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-09-06 03:42:38
Last Modified: 2018-09-07 11:58:50