Evolutionary history of human Plasmodium vivax revealed by genome-wide analyses of related ape parasites
- Loy, DE; Plenderleith, LJ; Sundararaman, SA; Liu, W; Gruszczyk, J; Chen, YJ; Trimboli, S; Learn, GH; MacLean, OA; Morgan, ALK; Li, Y; Avitto, AN; Giles, J; Calvignac-Spencer, S; Sachse, A; Leendertz, FH; Speede, S; Ayouba, A; Peeters, M; Rayner, JC; Tham, WH; Sharp, PM; Hahn, BH;
Publication Year 2018, Volume 115, Issue #36, Page E8450-E8459
- Journal Title
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type
- Journal Article
- Wild-living African apes are endemically infected with parasites that are closely related to human Plasmodium vivax, a leading cause of malaria outside Africa. This finding suggests that the origin of P. vivax was in Africa, even though the parasite is now rare in humans there. To elucidate the emergence of human P. vivax and its relationship to the ape parasites, we analyzed genome sequence data of P. vivax strains infecting six chimpanzees and one gorilla from Cameroon, Gabon, and Cote d'Ivoire. We found that ape and human parasites share nearly identical core genomes, differing by only 2% of coding sequences. However, compared with the ape parasites, human strains of P. vivax exhibit about 10-fold less diversity and have a relative excess of nonsynonymous nucleotide polymorphisms, with site-frequency spectra suggesting they are subject to greatly relaxed purifying selection. These data suggest that human P. vivax has undergone an extreme bottleneck, followed by rapid population expansion. Investigating potential host-specificity determinants, we found that ape P. vivax parasites encode intact orthologs of three reticulocyte-binding protein genes (rbp2d, rbp2e, and rbp3), which are pseudogenes in all human P. vivax strains. However, binding studies of recombinant RBP2e and RBP3 proteins to human, chimpanzee, and gorilla erythrocytes revealed no evidence of host-specific barriers to red blood cell invasion. These data suggest that, from an ancient stock of P. vivax parasites capable of infecting both humans and apes, a severely bottlenecked lineage emerged out of Africa and underwent rapid population growth as it spread globally.
- WEHI Research Division(s)
- Infection And Immunity
- PubMed ID
- Publisher's Version
- Open Access at Publisher's Site
- Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-08-27 09:10:43Last Modified: 2018-09-24 04:22:41