Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation
- Author(s)
- Cao, H; Biondo, M; Lioe, H; Busfield, S; Rayzman, V; Nieswandt, B; Bork, K; Harrison, LC; Auyeung, P; Farkas, H; Csuka, D; Pelzing, M; Dower, S; Wilson, MJ; Nash, A; Nolte, MW; Panousis, C;
- Details
- Publication Year 2018-10,Volume 142,Issue #4,Page 1355-1358
- Journal Title
- Journal of Allergy and Clinical Immunology
- Publication Type
- Journal Article
- Abstract
- HAE results in swelling due to KKS dysregulation and bradykinin production. FXII initiates the KKS and we have developed a human antibody that potently inhibits FXII protease activity as a novel prophylactic therapy for HAE.
- Publisher
- Elsevier
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 29936101
- Publisher's Version
- https://doi.org/10.1016/j.jaci.2018.06.014
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-06-27 09:13:23
Last Modified: 2018-10-22 10:15:46