Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane
Journal Title
European Journal of Medicinal Chemistry
Publication Type
Journal Article
Abstract
The design, synthesis and evaluation of a small series of potent amphiphilic norbornane antibacterial agents has been performed (compound 10 MIC=0.25mug/mL against MRSA). Molecular modelling indicates rapid aggregation of this class of antibacterial agent prior to membrane association and insertion. Two fluorescent analogues (compound 29 with 4-amino-naphthalimide and 34 with 4-nitrobenz-2-oxa-1,3-diazole fluorophores) with good activity (MIC=0.5mug/mL against MRSA) were also constructed and confocal microscopy studies indicate that the primary site of interaction for this family of compounds is the bacterial membrane.
Publisher
Elsevier
Research Division(s)
Chemical Biology
PubMed ID
30316060
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2018-10-23 08:48:41
Last Modified: 2018-10-23 08:52:00
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