Constitutive overexpression of TNF in BPSM1 mice causes iBALT and bone marrow nodular lymphocytic hyperplasia

Seillet, C; Carr, E; Lacey, D; Stutz, MD; Pellegrini, M; Whitehead, L; Rimes, J; Hawkins, ED; Roediger, B; Belz, GT; Bouillet, P

Author(s): Seillet, C; Carr, E; Lacey, D; Stutz, MD; Pellegrini, M; Whitehead, L; Rimes, J; Hawkins, ED; Roediger, B; Belz, GT; Bouillet, P;
Details: Publication Year 2018-08-14,Volume 97,Issue #1,Page 29-38
Journal Title: Immunology and Cell Biology
Publication Type: Journal Article
Abstract: BPSM1 (Bone phenotype spontaneous mutant 1) mice develop severe polyarthritis and heart valve disease as a result of a spontaneous mutation in the Tnf gene. In these mice, the insertion of a retrotransposon in the 3' untranslated region of Tnf causes a large increase in the expression of the cytokine. We have found that these mice also develop inducible bronchus-associated lymphoid tissue (iBALT), as well as nodular lymphoid hyperplasia (NLH) in the bone marrow. Loss of TNFR1 prevents the development of both types of follicles, but deficiency of TNFR1 in the hematopoietic compartment only prevents the iBALT and not the NLH phenotype. We show that the development of arthritis and heart valve disease does not depend on the presence of the tertiary lymphoid tissues (TLOs). Interestingly, while loss of IL-17 or IL-23 limits iBALT and NLH development to some extent, it has no effect on polyarthritis or heart valve disease in BPSM1 mice. This article is protected by copyright. All rights reserved.
Publisher: Wiley
Research Division(s): Immunology; Infection And Immunity; Molecular Immunology; Molecular Genetics Of Cancer; Systems Biology And Personalised Medicine
PubMed ID: 30107066
Link To PubMed Central Version: https://ww.-ncbi.nlm.nih.gov/pmc/articles/PMC6378607/
Publisher's Version: https://doi.org/10.1111/imcb.12197
NHMRC Grants: NHMRC/1042629, NHMRC/1051506, NHMRC/1054925, NHMRC/1086977, NHMRC/1122277, NHMRC/1123000, NHMRC/1127885, NHMRC/461221,
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Creation Date: 2018-10-22 02:37:38

Last Modified: 2019-12-03 03:50:00