Stemformatics: visualize and download curated stem cell data
Journal Title
Nucleic Acids Research
Publication Type
Journal Article in press
Abstract
Stemformatics is an established gene expression data portal containing over 420 public gene expression datasets derived from microarray, RNA sequencing and single cell profiling technologies. Developed for the stem cell community, it has a major focus on pluripotency, tissue stem cells, and staged differentiation. Stemformatics includes curated 'collections' of data relevant to cell reprogramming, as well as hematopoiesis and leukaemia. Rather than simply rehosting datasets as they appear in public repositories, Stemformatics uses a stringent set of quality control metrics and its own pipelines to process handpicked datasets from raw files. This means that about 30% of datasets processed by Stemformatics fail the quality control metrics and never make it to the portal, ensuring that Stemformatics data are of high quality and have been processed in a consistent manner. Stemformatics provides easy-to-use and intuitive tools for biologists to visually explore the data, including interactive gene expression profiles, principal component analysis plots and hierarchical clusters, among others. The addition of tools that facilitate cross-dataset comparisons provides users with snapshots of gene expression in multiple cell and tissues, assisting the identification of cell-type restricted genes, or potential housekeeping genes. Stemformatics is freely available at stemformatics.org.
Publisher
Oxford Academic
Research Division(s)
Molecular Medicine
PubMed ID
30407577
Open Access at Publisher's Site
https://doi.org/10.1093/nar/gky1064
ARC Grants
ARC/FT150100330,
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2018-11-20 09:12:48
Last Modified: 2018-11-20 11:43:38
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