The molecular details of cytokine signalling via the JAK/STAT pathway
- Author(s)
- Morris, R; Kershaw, NJ; Babon, JJ;
- Details
- Publication Year 2018-12,Volume 27,Issue #12,Page 1984-2009
- Journal Title
- Protein Science
- Publication Type
- Journal Article
- Abstract
- More than 50 cytokines signal via the JAK/STAT pathway to orchestrate haematopoiesis, induce inflammation and control the immune response. Cytokines are secreted glycoproteins that act as intercellular messengers, inducing proliferation, differentiation, growth or apoptosis of their target cells. They act by binding to specific receptors on the surface of target cells and switching on a phosphotyrosine-based intracellular signalling cascade initiated by kinases then propagated and effected by SH2 domain-containing transcription factors. As cytokine signalling is proliferative and often inflammatory it is tightly regulated in terms of both amplitude and duration. Here we review molecular details of the cytokine-induced signalling cascade and describe the architectures of the proteins involved, including the receptors, kinases and transcription factors that initiate and propagate signalling and the regulatory proteins that control it. This article is protected by copyright. All rights reserved.
- Publisher
- Wiley
- Research Division(s)
- Structural Biology
- PubMed ID
- 30267440
- Link To PubMed Central Version
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237706/
- Publisher's Version
- https://doi.org/10.1002/pro.3519
- NHMRC Grants
- NHMRC/1122999, NHMRC/1113577,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-10-11 04:23:17
Last Modified: 2019-12-03 02:41:54