Dietary cows' milk protein A1 beta-casein increases the incidence of T1D in NOD mice
Details
Publication Year 2018-09-12,Volume 10,Issue #9,Page pii: E1291
Journal Title
Nutrients
Publication Type
Journal Article
Abstract
The contribution of cows' milk containing beta-casein protein A1 variant to the development of type 1 diabetes (T1D) has been controversial for decades. Despite epidemiological data demonstrating a relationship between A1 beta-casein consumption and T1D incidence, direct evidence is limited. We demonstrate that early life exposure to A1 beta-casein through the diet can modify progression to diabetes in non-obese diabetic (NOD) mice, with the effect apparent in later generations. Adult NOD mice from the F0 generation and all subsequent generations (F1 to F4) were fed either A1 or A2 beta-casein supplemented diets. Diabetes incidence in F0(-)F2 generations was similar in both cohorts of mice. However, diabetes incidence doubled in the F3 generation NOD mice fed an A1 beta-casein supplemented diet. In F4 NOD mice, subclinical insulitis and altered glucose handling was evident as early as 10 weeks of age in A1 fed mice only. A significant decrease in the proportion of non-conventional regulatory T cell subset defined as CD4(+)CD25(-)FoxP3(+) was evident in the F4 generation of A1 fed mice. This feeding intervention study demonstrates that dietary A1 beta-casein may affect glucose homeostasis and T1D progression, although this effect takes generations to manifest.
Publisher
MDPI
Research Division(s)
Bioinformatics
PubMed ID
30213104
Open Access at Publisher's Site
https://doi.org/10.3390/nu10091291
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2018-09-21 02:32:23
Last Modified: 2018-10-22 10:17:01
An error has occurred. This application may no longer respond until reloaded. Reload 🗙