Taking sharper pictures of malaria with combined antibodies to measure exposure recency assays
- Author(s)
- Greenhouse, B; Smith, DL; Rodriguez-Barraquer, I; Mueller, I; Drakeley, CJ;
- Details
- Publication Year 2018-11,Volume 99,Issue #5,Page 1120-1127
- Journal Title
- American Journal of Tropical Medicine and Hygiene
- Publication Type
- Journal Article
- Abstract
- Antibodies directed against malaria parasites are easy and inexpensive to measure but remain an underused surveillance tool because of a lack of consensus on what to measure and how to interpret results. High-throughput screening of antibodies from well-characterized cohorts offers a means to substantially improve existing assays by rationally choosing the most informative sets of responses and analytical methods. Recent data suggest that high-resolution information on malaria exposure can be obtained from a small number of samples by measuring a handful of properly chosen antibody responses. In this review, we discuss how standardized multi-antibody assays can be developed and efficiently integrated into existing surveillance activities, with potential to greatly augment the breadth and quality of information available to direct and monitor malaria control and elimination efforts.
- Publisher
- ASTMH
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 30298804
- Publisher's Version
- https://doi.org/10.4269/ajtmh.18-0303
- Open Access at Publisher's Site
https://doi.org/10.4269/ajtmh.18-0303- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-10-11 04:23:15
Last Modified: 2018-11-20 01:34:10