GM-CSF as a therapeutic target in inflammatory diseases.
Details
Publication Year 2013-12,Volume 56,Issue #4,Page 675-682
Journal Title
Molecular Immunology
Publication Type
Journal Article
Abstract
GM-CSF is a well-known haemopoietic growth factor that is used in the clinic to correct neutropaenia, usually as a result of chemotherapy. GM-CSF also has many pro-inflammatory functions and recent data implicates GM-CSF as a key factor in Th17 driven autoimmune inflammatory conditions. In this review we summarize the findings that have led to the development of GM-CSF antagonists for the treatment of autoimmune diseases like rheumatoid arthritis (RA) and discuss some results of recent clinical trials of these agents.
Publisher
Elsevier
Keywords
GM-CSF ; Autoimmunity ; Inflammatory disease ; Rheumatoid arthritis ; Cytokines ; Autoimmune disease ; GM-CSF receptor ; Th17 pathway ; T cells
Research Division(s)
Inflammation
Terms of Use/Rights Notice
Copyright © 2013 Elsevier Ltd. All rights reserved.


Creation Date: 2013-12-01 12:00:00
An error has occurred. This application may no longer respond until reloaded. Reload 🗙