MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer.
- Author(s)
- Johanson, TM; Lew, AM; Chong, MM;
- Details
- Publication Year 2013-10,Volume 3,Issue #10,Page 130144
- Journal Title
- Open Biology
- Publication Type
- Journal Article
- Abstract
- The ribonuclease III enzymes Drosha and Dicer are renowned for their central roles in the biogenesis of microRNAs (miRNAs). For many years, this has overshadowed the true versatility and importance of these enzymes in the processing of other RNA substrates. For example, Drosha also recognizes and cleaves messenger RNAs (mRNAs), and potentially ribosomal RNA. The cleavage of mRNAs occurs via recognition of secondary stem-loop structures similar to miRNA precursors, and is an important mechanism of repressing gene expression, particularly in progenitor/stem cell populations. On the other hand, Dicer also has critical roles in genome regulation and surveillance. These include the production of endogenous small interfering RNAs from many sources, and the degradation of potentially harmful short interspersed element and viral RNAs. These findings have sparked a renewed interest in these enzymes, and their diverse functions in biology.
- Publisher
- Royal Society Publishing
- Keywords
- RNase III enzymes ; Drosha Dicer ; microRNA ; RNA processing
- Research Division(s)
- Immunology
- Publisher's Version
- https://doi.org/10.1098/rsob.130144
- Open Access at Publisher's Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814725/- Terms of Use/Rights Notice
- Copyright © The Royal Society 2013
Creation Date: 2013-10-01 12:00:00
Last Modified: 2015-09-04 11:25:55